Measurement of Isoprostanes as Markers of Oxidative Stress in Neuronal Tissue

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Isoprostanes - A novel major group of oxidative stress markers.

Isoprostanes are a recently discovered group of prostaglandin isomers. Results of previous studies suggest that they can be used as oxidative stress markers, because in a number of cardiovascular, pulmonary and neurological diseases their levels in biological samples considerably increase. It has been found that people suffering from diabetes, obesity, homozygous familial hypercholesterolemia, ...

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Insights into oxidative stress: the isoprostanes.

Oxidative stress, characterized by an imbalance between increased exposure to free radicals and antioxidant defenses, is a prominent feature of many acute and chronic diseases and even the normal aging process. However, definitive evidence for this association has often been lacking due to recognized shortcomings with methods previously available to assess oxidant stress status in vivo in human...

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ژورنال

عنوان ژورنال: Current Protocols in Toxicology

سال: 2009

ISSN: 1934-9254,1934-9262

DOI: 10.1002/0471140856.tx1214s39